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Antibody-drug conjugate-based therapeutics: state of the science

Antigen presentation is impaired under oxygen scarcity, which reduces MHC class I and II expression and affects the antigen processing machinery in both tumor cells and antigen-presenting cells (APCs) [75]

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We derived this estimate by dividing the observed effect sizes of significantly differentially methylated CpG sites in our dataset (0.020.07 for 8/9 CpG sites) by the estimated group exposure contrast (the difference in median total hair mercury was 12.40.48 = 11.92 g/g), which yielded slopes ranging from (0.02/11.92 =) 0.002 to (0.07/11.92 =) 0.006

Inhibition of ALK is a target for slowing proliferation in NSCLC