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As many as 65% exceed safe endotoxin thresholds that can cause inflammatory reactions

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Polyphenols are found to have modulatory effects on mitogen-activated protein kinases (MAPKs), NF-B, phosphatidylinositol 3-kinase (PI3K/Akt), and Wnt/-catenin networks and prevent the occurrence of inflammatory disorders (Jantan et al., 2021)

This proline-rich sequence introduces conformational rigidity that strongly resists proteolytic degradation by trypsin, chymotrypsin, and catheptic proteases